MGF IGF-1 Ec – 5MG

Scientific Overview of MGF IGF-1 EC

MGF (Mechano-Growth Factor) is a splice variant of the IGF 1 (Insulin-like Growth Factor-1) gene, specifically the EC (or Eb/c) isoform that includes a unique C-terminal “E-domain”. Research suggests that the C-terminal segment of this splice variant may act independently and support tissue repair, regeneration, and recovery following mechanical or metabolic stress. Investigations propose that MGF IGF-1 EC may engage pathways in muscle, cartilage and cardiac tissues, influencing cellular survival, satellite cell activation, and response to mechanical overload, though the full mechanisms remain under study.

Alternative Names: MGF, IGF-1Ec E-domain peptide, MGF C-terminal peptide

Studies and Research Data

Tissue Repair & Recovery Pathways

Preclinical models demonstrate that MGF IGF-1 EC is expressed in tissues undergoing mechanical overload or injury—such as skeletal muscle after eccentric exercise. In experimental settings, exposure to the peptide or its synthetic mimetics was associated with enhanced activation of satellite cells, suggesting a potential role in promoting early repair-phase processes.

Neuroprotection and Non-muscle Tissues

Research using neural injury models (e.g., brain ischemia) found that the C-terminal MGF peptide provided significant protective benefit to vulnerable neuronal populations. In one study, the synthetic peptide conferred neuroprotection independently of the canonical IGF-1 receptor, which suggests a novel mode of action.

Cartilage, Cardiac & Mechanical Stress Contexts

Further experimental work suggests that MGF IGF-1 EC may assist cells in cartilage and cardiac tissue to resist mechanical stress, apoptosis or ischemia. For example, studies in cardiac infarction models showed reduced cardiomyocyte damage when the peptide was applied. These results support its potential as a repair-modulating agent across tissue types.

Mechanistic Insights & Splice-Variant Biology

Mechanistic research indicates that the E-domain (C-terminal) region of IGF-1Ec may localize to nuclei, modulate transcriptional responses, and influence cell survival pathways distinct from traditional IGF-1 signaling. The presence of this domain highlights the complexity of IGF-1 gene splicing and the possibility of isoform-specific biological actions.

Conclusion

MGF IGF-1 Ec is a synthetic peptide derived from the C-terminal splice variant of IGF-1 with research interest in tissue repair, regeneration, mechanical stress response, and neural protection. While preclinical results show promising directions, the exact mechanisms, tissue-specific actions, and translational relevance remain incompletely defined. Use of this peptide for research purposes should be understood as exploratory and context-dependent.

References

1. Dłużniewska J., Sarnowska A., Beresewicz M., Johnson I., Srai S.K.S., Ramesh B., et al. A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia. FASEB J. 2005 Nov;19(13):1896-1898.
2. Zabłocka B., Goldspink P.H., Goldspink G., Górecki D.C. Mechano-Growth Factor: an important cog or a loose screw in the repair machinery? Front Endocrinol. 2012;3:131.
3. Fornaro M., et al. Mechano-growth factor peptide, the COOH-terminus of IGF-1 Ec: signalling for repair and regeneration. Am J Physiol Endocrinol Metab. 2014 Nov;307(9):E1-E10.
4. Matheny R.W. Jr., Nindl B.C., Adamo M.L. Minireview: Mechano-Growth Factor: a putative product of IGF-1 gene expression involved in tissue repair and regeneration. Endocrinology. 2010 Mar;151(3):865-875.

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